Who owns Karyopharm Therapeutics Inc.?
Institutional ownership of KPTI from SEC Form 13F filings across 71 reporting managers. All positions are from one synchronized reporting period — 2026-06-30 books, filed up to 45 days after quarter end — so every row is comparable.
71
13F holders
$117.8M
value, 2026 filers
54.6%
of shares outstanding (12.4M sh)
27
new positions (2026 filers)
Top institutional holders
ordered by shares owned · positions as of 2026-06-30· % of fund = share of the manager's own book · % of co. = share of KPTI's shares outstanding
| # | Manager | Shares | Value | % of fund | % of co. | Δ shares QoQ |
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5M | $14.9M | 0.0% | 6.7% | -15.8% |
| 2 | GOLDMAN SACHS GROUP INC | 1.4M | $13.9M | 0.0% | 6.3% | +50.3% |
| 3 | BlackRock, Inc. | 1.4M | $13.9M | 0.0% | 6.3% | +479.3% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 958,979 | $9.4M | 0.0% | 4.2% | -35.2% |
| 5 | Catalio Capital Management, LP | 940,855 | $9.2M | 1.7% | 4.2% | +4.8% |
| 6 | TWO SIGMA INVESTMENTS, LP | 695,264 | $6.8M | 0.0% | 3.1% | +359.7% |
| 7 | GEODE CAPITAL MANAGEMENT, LLC | 531,231 | $5.2M | 0.0% | 2.3% | +157.7% |
| 8 | Ghisallo Capital Management LLCNEW | 500,000 | $4.9M | 0.1% | 2.2% | new |
| 9 | UBS Group AG | 353,545 | $3.5M | 0.0% | 1.6% | +82.2% |
| 10 | Brevan Howard Capital Management LP | 309,817 | $3.0M | 0.0% | 1.4% | +45.9% |
| 11 | MILLENNIUM MANAGEMENT LLC | 305,676 | $3.0M | 0.0% | 1.3% | -27.3% |
| 12 | Davidson Kempner Capital Management LP | 300,000 | $2.9M | 0.0% | 1.3% | 0.0% |
| 13 | ACADIAN ASSET MANAGEMENT LLC | 298,997 | $2,916 | 0.0% | 1.3% | +20.1% |
| 14 | SILVERARC CAPITAL MANAGEMENT, LLCNEW | 297,460 | $2.9M | 0.3% | 1.3% | new |
| 15 | JPMORGAN CHASE & CO | 207,609 | $2.1M | 0.0% | 0.9% | +43978.3% |
| 16 | MORGAN STANLEY | 202,506 | $2.0M | 0.0% | 0.9% | +990.5% |
| 17 | BNP PARIBAS FINANCIAL MARKETS | 188,038 | $1.8M | 0.0% | 0.8% | +223754.8% |
| 18 | BARCLAYS PLC | 165,904 | $1.6M | 0.0% | 0.7% | +2134.7% |
| 19 | NORTHERN TRUST CORP | 160,006 | $1.6M | 0.0% | 0.7% | +315.0% |
| 20 | VANGUARD FIDUCIARY TRUST CO | 145,401 | $1.4M | 0.0% | 0.6% | +26.5% |
| 21 | VANGUARD PORTFOLIO MANAGEMENT LLCNEW | 134,818 | $1.3M | 0.0% | 0.6% | new |
| 22 | MARSHALL WACE, LLP | 128,451 | $1.3M | 0.0% | 0.6% | 0.0% |
| 23 | Jump Financial, LLC | 94,000 | $918,380 | 0.0% | 0.4% | -64.1% |
| 24 | Invesco Ltd. | 90,304 | $882,270 | 0.0% | 0.4% | +439.5% |
| 25 | Connor, Clark & Lunn Investment Management Ltd. | 76,397 | $746,399 | 0.0% | 0.3% | -3.4% |
Source: SEC Form 13F-HR filings (institutional managers over $100M in US-listed positions). 13Fs disclose long positions only, up to 45 days after quarter end; each manager's latest filed quarter is shown per row and dollar values are the manager's filed marks. Aggregates labeled "2026 filers" count only managers whose latest book is a 2026 quarter. Related: valuation · options positioning · supply chain. Research, not investment advice.