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Palo Alto Investors LP

Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-06-30 · filed with the SEC up to 45 days after quarter end · CIK 0001306923

$723.7M

disclosed book value

52

positions

10.4%

largest position share

Positions, as of 2026-06-30

top 52 of 52 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held

#IssuerSharesValue% of book
1PTCTPTC THERAPEUTICS INC918,846$75.0M10.4%
2ACADACADIA PHARMACEUTICALS INC2.9M$72.5M10%
3INSMINSMED INC413,980$44.1M6.1%
4MIRMMIRUM PHARMACEUTICALS INC348,808$40.8M5.6%
5ANABANAPTYSBIO INC603,489$40.7M5.6%
6BMRNBIOMARIN PHARMACEUTICAL INC682,777$39.1M5.4%
7DYNDYNE THERAPEUTICS INC1.6M$36.6M5.1%
8UTHRUNITED THERAPEUTICS CORP62,587$33.9M4.7%
9IRONDISC MEDICINE INC416,646$30.5M4.2%
10BIIBBIOGEN INC140,279$30.3M4.2%
11IOVAIOVANCE BIOTHERAPEUTICS INC5.3M$22.0M3%
12RAREULTRAGENYX PHARMACEUTICAL IN596,495$19.9M2.8%
13NOVOCURE LTD1.3M$19.4M2.7%
14SNDXSYNDAX PHARMACEUTICALS INC864,986$18.9M2.6%
15ANNXANNEXON INC2.9M$16.8M2.3%
16BCAXBICARA THERAPEUTICS INC550,408$16.3M2.3%
17CDNACAREDX INC531,870$15.2M2.1%
18CLDXCELLDEX THERAPEUTICS INC399,856$14.9M2.1%
19CMPXCOMPASS THERAPEUTICS INC5.8M$12.8M1.8%
20ALKERMES PLC242,560$12.7M1.8%
21TRAXFIRST TRACKS BIOTHERAPEUTICS603,489$12.1M1.7%
22PROTHENA CORP PLC1.1M$11.2M1.5%
23TVTXTRAVERE THERAPEUTICS INC167,525$9.5M1.3%
24TSHATAYSHA GENE THERAPIES INC1.4M$9.5M1.3%
25ACRSACLARIS THERAPEUTICS INC1.6M$8.5M1.2%
26AGIOAGIOS PHARMACEUTICALS INC213,601$7.9M1.1%
27CAPRCAPRICOR THERAPEUTICS INC229,763$5.5M0.8%
28ALGNALIGN TECHNOLOGY INC31,389$5.3M0.7%
29ORKAORUKA THERAPEUTICS INC - Restricted33,546$3.2M0.4%
30XENEXENON PHARMACEUTICALS INC51,345$3.1M0.4%
31NBIXNEUROCRINE BIOSCIENCES INC18,117$3.1M0.4%
32EWEDWARDS LIFESCIENCES CORP33,640$3.0M0.4%
33STOKSTOKE THERAPEUTICS INC84,631$2.8M0.4%
34CYTKCYTOKINETICS INC32,195$2.7M0.4%
35PYXSPYXIS ONCOLOGY INC864,277$2.6M0.4%
36EHTHEHEALTH INC1.5M$2.2M0.3%
37CRISPR THERAPEUTICS AG39,605$2.2M0.3%
38SGMTSAGIMET BIOSCIENCES INC-A250,000$1.9M0.3%
39NUVBNUVATION BIO INC326,609$1.9M0.3%
40BNTXBIONTECH SE-ADR19,614$1.8M0.3%
41CMPSCOMPASS PATHWAYS PLC ADR115,616$1.6M0.2%
42HUMHUMANA INC3,985$1.6M0.2%
43NEWAMSTERDAM PHARMA CO NV44,359$1.5M0.2%
44VSTMVERASTEM INC309,685$1.2M0.2%
45MDGLMADRIGAL PHARMACEUTICALS INC1,787$959,5300.1%
46UROGEN PHARMA LTD24,500$901,6000.1%
47BCYCBICYCLE THERAPEUTICS PLC-ADR201,890$856,0140.1%
48XERSXERIS BIOPHARMA HOLDINGS INC104,410$826,9270.1%
49ABEOABEONA THERAPEUTICS INC108,865$672,7860.1%
50INSPINSPIRE MEDICAL SYSTEMS INC8,772$391,3190.1%
51PROQR THERAPEUTICS NV188,807$351,1810%
52ALDXALDEYRA THERAPEUTICS INC155,709$331,6600%

Source: SEC Form 13F-HR, reporting period 2026-06-30. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.

EvidInvest is an independent research and information tool. Figures are calculated from public SEC filings and third-party market data and are provided for informational and educational purposes only. EvidInvest does not provide investment advice, brokerage, or financial services, and is not affiliated with any company it covers. Verify all figures against primary sources before making any decision.