Who owns Septerna, Inc.?
Prices and market caps: Cboe delayed data, at least 15 minutes delayed. Not real-time. Fundamentals from company filings.
Institutional ownership of SEPN from SEC Form 13F filings across 153 reporting managers. All positions are from one synchronized reporting period — 2026-06-30 books, filed up to 45 days after quarter end — so every row is comparable.
As of the 2026-06-30 reporting period, 153 institutions disclosed 47.2M shares of Septerna, Inc. worth $1.58B — about 104.9% of shares outstanding; the largest disclosed holder is RA CAPITAL MANAGEMENT, L.P.. Source: SEC Form 13F filings, parsed by EvidInvest.
153
13F holders
$1.58B
value, 2026 filers
104.9%
of shares outstanding (47.2M sh)
47
new positions (2026 filers)
Top institutional holders
ordered by shares owned · positions as of 2026-06-30 · % of fund = share of the manager's own book · % of co. = share of SEPN's shares outstanding
| # | Manager | Shares | Value | % of fund | % of co. | Δ shares QoQ |
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 7.0M | $234.3M | 2.0% | 15.5% | 0.0% |
| 2 | TRV GP V, LLC | 6.2M | $208.2M | 41.8% | 13.8% | 0.0% |
| 3 | Driehaus Capital Management LLC | 4.4M | $148.5M | 0.9% | 9.8% | +0.9% |
| 4 | TRV GP VI, LLC | 4.2M | $141.0M | 60.7% | 9.4% | 0.0% |
| 5 | SAMSARA BIOCAPITAL, LLC | 3.1M | $105.5M | 8.7% | 7% | 0.0% |
| 6 | GOLDMAN SACHS GROUP INC | 3.1M | $102.6M | 0.0% | 6.8% | +5.4% |
| 7 | BlackRock, Inc. | 1.9M | $64.7M | 0.0% | 4.3% | +6.0% |
| 8 | Siren, L.L.C. | 1.9M | $63.6M | 1.3% | 4.2% | -5.0% |
| 9 | Avoro Capital Advisors LLC | 1.3M | $44.8M | 0.4% | 3% | 0.0% |
| 10 | Jupiter Topco LLCNEW | 1.3M | $43.7M | 0.0% | 2.9% | new |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $40.9M | 0.0% | 2.7% | +2.1% |
| 12 | PRIMECAP MANAGEMENT CO/CA/ | 1.2M | $39.1M | 0.0% | 2.6% | +11.3% |
| 13 | First Light Asset Management, LLC | 963,260 | $32.3M | 2.0% | 2.1% | +31.4% |
| 14 | ADAR1 Capital Management, LLC | 940,747 | $31.5M | 1.4% | 2.1% | -13.7% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 679,163 | $22.8M | 0.0% | 1.5% | +5.3% |
| 16 | STATE STREET CORP | 652,630 | $21.9M | 0.0% | 1.4% | +3.4% |
| 17 | LOOMIS SAYLES & CO L PNEW | 624,752 | $20.9M | 0.0% | 1.4% | new |
| 18 | Casdin Capital, LLC | 553,268 | $18.5M | 0.9% | 1.2% | 0.0% |
| 19 | Catalio Capital Management, LP | 536,152 | $18.0M | 3.4% | 1.2% | +82.1% |
| 20 | ALGERT GLOBAL LLC | 397,487 | $13.3M | 0.2% | 0.9% | +1789.6% |
| 21 | Balyasny Asset Management L.P. | 350,442 | $11.7M | 0.0% | 0.8% | +48.1% |
| 22 | Longaeva Partners L.P. | 298,171 | $10.0M | 0.2% | 0.7% | +299.9% |
| 23 | Soleus Capital Management, L.P. | 275,000 | $9.2M | 0.3% | 0.6% | 0.0% |
| 24 | VANGUARD PORTFOLIO MANAGEMENT LLC | 230,184 | $7.7M | 0.0% | 0.5% | +18.0% |
| 25 | Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $7.5M | 0.0% | 0.5% | -0.6% |
Source: SEC Form 13F-HR filings (institutional managers over $100M in US-listed positions). 13Fs disclose long positions only, up to 45 days after quarter end; each manager's latest filed quarter is shown per row and dollar values are the manager's filed marks. Aggregates labeled "2026 filers" count only managers whose latest book is a 2026 quarter. Related: valuation · options positioning · supply chain. Research, not investment advice.