Holders — by stockHoldings — by fund
Siren, L.L.C.
Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-06-30 · filed with the SEC up to 45 days after quarter end · CIK 0002005245
$4.94B
disclosed book value
116
positions
10.7%
largest position share
Positions, as of 2026-06-30
top 100 of 116 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held
| # | Issuer | Shares | Value | % of book |
|---|---|---|---|---|
| 1 | SRRKScholar Rock Holding Corp | 9.6M | $526.6M | 10.7% |
| 2 | KYMRKymera Therapeutics Inc | 2.9M | $336.7M | 6.8% |
| 3 | ERASErasca Inc | 11.4M | $208.8M | 4.2% |
| 4 | MANEVeradermics Inc | 1.7M | $203.5M | 4.1% |
| 5 | TNGXTango Therapeutics Inc | 6.2M | $193.2M | 3.9% |
| 6 | RVMDRevolution Medicines Inc | 900,000 | $168.6M | 3.4% |
| 7 | BCAXBicara Therapeutics Inc | 5.6M | $166.4M | 3.4% |
| 8 | ARWRArrowhead Pharmaceuticals Inc | 1.7M | $139.8M | 2.8% |
| 9 | ONCBeOne Medicines AG | 465,000 | $132.5M | 2.7% |
| 10 | EWTXEdgewise Therapeutics Inc | 3.2M | $129.4M | 2.6% |
| 11 | RYTMRhythm Pharmaceuticals Inc | 1.1M | $126.2M | 2.6% |
| 12 | LXRXLexicon Pharmaceuticals Inc | 44.3M | $106.3M | 2.2% |
| 13 | ELVNEnliven Therapeutics Inc | 1.8M | $90.1M | 1.8% |
| 14 | SYRESpyre Therapeutics Inc | 968,598 | $86.0M | 1.7% |
| 15 | PBLSParabilis Medicines Inc | 3.0M | $81.9M | 1.7% |
| 16 | XENEXenon Pharmaceuticals Inc | 1.3M | $79.6M | 1.6% |
| 17 | SLDBSolid Biosciences Inc | 7.7M | $76.8M | 1.6% |
| 18 | ABVXAbivax SA | 576,000 | $76.8M | 1.6% |
| 19 | COAGHemab Therapeutics Holdings Inc | 2.1M | $76.6M | 1.6% |
| 20 | RCUSArcus Biosciences Inc | 2.4M | $74.6M | 1.5% |
| 21 | COGTCogent Biosciences Inc | 1.9M | $72.0M | 1.5% |
| 22 | RLAYRelay Therapeutics Inc | 3.6M | $68.3M | 1.4% |
| 23 | TSHATaysha Gene Therapies Inc | 9.8M | $67.1M | 1.4% |
| 24 | DFTXDefinium Therapeutics Inc | 1.4M | $66.8M | 1.4% |
| 25 | STOKStoke Therapeutics Inc | 2.0M | $65.3M | 1.3% |
| 26 | IRONDisc Medicine Inc | 888,401 | $65.0M | 1.3% |
| 27 | CYTKCytokinetics Inc | 758,952 | $64.7M | 1.3% |
| 28 | SEPNSepterna Inc | 1.9M | $63.6M | 1.3% |
| 29 | OLMAOlema Pharmaceuticals Inc | 4.9M | $60.8M | 1.2% |
| 30 | CRNXCrinetics Pharmaceuticals Inc | 1.4M | $53.2M | 1.1% |
| 31 | KLRAKailera Therapeutics Inc | 2.2M | $48.8M | 1% |
| 32 | DYNDyne Therapeutics, Inc | 2.1M | $47.3M | 1% |
| 33 | GPCRStructure Therapeutics Inc | 872,967 | $46.9M | 0.9% |
| 34 | TBLATaboola.com Ltd | 8.4M | $42.1M | 0.9% |
| 35 | PVLAPalvella Therapeutics Inc | 257,485 | $39.3M | 0.8% |
| 36 | SLNSilence Therapeutics PLC | 3.3M | $36.4M | 0.7% |
| 37 | DNLIDenali Therapeutics Inc | 1.4M | $35.9M | 0.7% |
| 38 | RELYRemitly Global Inc | 1.5M | $34.6M | 0.7% |
| 39 | CGEMCullinan Therapeutics Inc | 1.9M | $34.5M | 0.7% |
| 40 | COFCapital One Finl Corp | 171,615 | $34.4M | 0.7% |
| 41 | TRVITrevi Therapeutics Inc | 1.8M | $33.3M | 0.7% |
| 42 | ORICOric Pharmaceuticals Inc | 3.0M | $32.5M | 0.7% |
| 43 | GOOGLAlphabet Inc | 90,000 | $32.2M | 0.7% |
| 44 | DBVTDbv Technologies SA | 1.9M | $30.5M | 0.6% |
| 45 | ABSIAbsci Corp | 2.5M | $28.7M | 0.6% |
| 46 | SIONSionna Therapeutics Inc | 610,515 | $26.9M | 0.5% |
| 47 | RAPPRapport Therapeutics Inc | 641,469 | $26.7M | 0.5% |
| 48 | AMLXAmylyx Pharmaceuticals Inc | 1.5M | $26.6M | 0.5% |
| 49 | ANNXAnnexon Inc | 4.5M | $25.5M | 0.5% |
| 50 | MNPRMonopar Therapeutics Inc | 270,118 | $25.0M | 0.5% |
| 51 | ORKAOruka Therapeutics Inc | 250,000 | $23.8M | 0.5% |
| 52 | SPTXSeaport Therapeutics Inc | 1.1M | $23.8M | 0.5% |
| 53 | DMRADamora Therapeutics Inc | 900,000 | $23.4M | 0.5% |
| 54 | TYRATyra Biosciences Inc | 725,000 | $23.2M | 0.5% |
| 55 | ZURAZura Bio Ltd | 3.7M | $22.0M | 0.4% |
| 56 | TSMTaiwan Semiconductor Manufacturing Co Ltd | 44,700 | $21.3M | 0.4% |
| 57 | NVDANVIDIA Corp | 95,000 | $19.0M | 0.4% |
| 58 | RZLTRezolute Inc | 3.3M | $17.3M | 0.4% |
| 59 | MPLTMapLight Therapeutics Inc | 450,000 | $16.1M | 0.3% |
| 60 | NMRANeumora Therapeutics Inc | 8.5M | $14.4M | 0.3% |
| 61 | NBISNebius Group NV | 52,000 | $14.4M | 0.3% |
| 62 | MSFTMicrosoft Corp | 37,500 | $14.0M | 0.3% |
| 63 | CTMXCytomX Therapeutics Inc | 3.5M | $13.0M | 0.3% |
| 64 | GENBGenerate Biomedicines Inc | 736,104 | $12.4M | 0.3% |
| 65 | IKTInhibikase Therapeutics Inc | 5.8M | $11.9M | 0.2% |
| 66 | ADAGAdagene Inc | 2.7M | $11.2M | 0.2% |
| 67 | ENGNenGene Therapeutics Inc | 6.3M | $10.8M | 0.2% |
| 68 | WHWKWhitehawk Therapeutics Inc | 2.3M | $10.7M | 0.2% |
| 69 | DDOGDatadog Inc | 40,000 | $10.4M | 0.2% |
| 70 | NOWServiceNow Inc | 100,000 | $9.9M | 0.2% |
| 71 | AVGOBroadcom Inc | 25,000 | $9.4M | 0.2% |
| 72 | IONQIONQ Inc | 170,000 | $9.1M | 0.2% |
| 73 | MSFTMicrosoft CorpCALL | 24,000 | $9.0M | 0.2% |
| 74 | FROGJfrog Ltd | 95,500 | $8.7M | 0.2% |
| 75 | OCSOculis Holding AG | 625,000 | $8.7M | 0.2% |
| 76 | IRENIREN Ltd | 175,000 | $8.0M | 0.2% |
| 77 | AMZNAmazon.com Inc | 32,500 | $7.7M | 0.2% |
| 78 | CRWDCrowdStrike Holdings Inc | 10,000 | $7.6M | 0.2% |
| 79 | DSGNDesign Therapeutics Inc | 523,212 | $7.6M | 0.2% |
| 80 | PDDPDD Holdings Inc | 95,000 | $7.2M | 0.1% |
| 81 | MSLESatellos Bioscience Inc | 892,074 | $6.9M | 0.1% |
| 82 | DTDynatrace, Inc | 155,000 | $6.8M | 0.1% |
| 83 | AAPLApple IncCALL | 23,000 | $6.7M | 0.1% |
| 84 | TENXTenax Therapeutics Inc | 427,141 | $6.2M | 0.1% |
| 85 | VTVTvTv Therapeutics Inc | 163,000 | $6.1M | 0.1% |
| 86 | ELOXEloxx Pharmaceuticals Inc | 400,000 | $5.6M | 0.1% |
| 87 | AGMBAgomab Therapeutics NV | 411,250 | $5.3M | 0.1% |
| 88 | BABAAlibaba Group Holding Ltd | 50,000 | $4.8M | 0.1% |
| 89 | KRROKorro Bio Inc | 347,718 | $4.6M | 0.1% |
| 90 | CLBTCellebrite DI Ltd | 311,544 | $4.5M | 0.1% |
| 91 | IVVDInvivyd Inc | 5.0M | $4.4M | 0.1% |
| 92 | OUSTOuster Inc | 67,500 | $4.2M | 0.1% |
| 93 | PALIPalisade Bio Inc | 2.0M | $4.2M | 0.1% |
| 94 | AEVAAeva Technologies Inc | 145,459 | $4.2M | 0.1% |
| 95 | SEERSeer Inc | 2.5M | $4.1M | 0.1% |
| 96 | NBPNovaBridge Biosciences | 2.0M | $3.9M | 0.1% |
| 97 | GTLBGitLab Inc | 125,000 | $3.8M | 0.1% |
| 98 | ODTXOdyssey Therapeutics Inc | 200,000 | $3.7M | 0.1% |
| 99 | FHTXFoghorn Therapeutics Inc | 720,720 | $3.5M | 0.1% |
| 100 | AGENAgenus Inc | 1.1M | $3.3M | 0.1% |
Source: SEC Form 13F-HR, reporting period 2026-06-30. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.