Holders — by stockHoldings — by fund
Siren, L.L.C.
Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-03-31 · filed with the SEC up to 45 days after quarter end · CIK 0002005245
$3.61B
disclosed book value
100
positions
14.8%
largest position share
Positions, as of 2026-03-31
top 100 of 100 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held
| # | Issuer | Shares | Value | % of book |
|---|---|---|---|---|
| 1 | SRRKScholar Rock Holding Corp | 10.8M | $532.2M | 14.8% |
| 2 | KYMRKymera Therapeutics Inc | 3.2M | $265.4M | 7.4% |
| 3 | ERASErasca Inc | 11.2M | $181.9M | 5% |
| 4 | EWTXEdgewise Therapeutics Inc | 4.4M | $139.6M | 3.9% |
| 5 | ONCBeOne Medicines AG | 465,000 | $138.1M | 3.8% |
| 6 | TNGXTango Therapeutics Inc | 5.7M | $118.3M | 3.3% |
| 7 | BCAXBicara Therapeutics Inc | 5.8M | $115.4M | 3.2% |
| 8 | RVMDRevolution Medicines Inc | 1.1M | $108.0M | 3% |
| 9 | ARWRArrowhead Pharmaceuticals Inc | 1.6M | $101.3M | 2.8% |
| 10 | MANEVeradermics Inc | 1.5M | $95.1M | 2.6% |
| 11 | XENEXenon Pharmaceuticals Inc | 1.3M | $76.7M | 2.1% |
| 12 | OLMAOlema Pharmaceuticals Inc | 4.8M | $70.9M | 2% |
| 13 | CRNXCrinetics Pharmaceuticals Inc | 1.9M | $69.1M | 1.9% |
| 14 | LXRXLexicon Pharmaceuticals Inc | 44.3M | $69.1M | 1.9% |
| 15 | COGTCogent Biosciences Inc | 1.7M | $65.8M | 1.8% |
| 16 | STOKStoke Therapeutics Inc | 2.0M | $65.0M | 1.8% |
| 17 | RCUSArcus Biosciences Inc | 3.0M | $65.0M | 1.8% |
| 18 | GPCRStructure Therapeutics Inc | 1.3M | $64.0M | 1.8% |
| 19 | IRONDisc Medicine Inc | 988,401 | $63.2M | 1.8% |
| 20 | RYTMRhythm Pharmaceuticals Inc | 725,511 | $63.1M | 1.7% |
| 21 | SLDBSolid Biosciences Inc | 7.7M | $55.4M | 1.5% |
| 22 | SEPNSepterna Inc | 2.0M | $48.1M | 1.3% |
| 23 | 260Centessa Pharmaceuticals PLC | 1.1M | $41.8M | 1.2% |
| 24 | SYRESpyre Therapeutics Inc | 818,598 | $41.3M | 1.1% |
| 25 | CYTKCytokinetics Inc | 613,952 | $40.5M | 1.1% |
| 26 | DYNDyne Therapeutics, Inc | 2.2M | $40.4M | 1.1% |
| 27 | TSHATaysha Gene Therapies Inc | 8.8M | $39.5M | 1.1% |
| 28 | DBVTDbv Technologies SA | 1.9M | $38.8M | 1.1% |
| 29 | ORICOric Pharmaceuticals Inc | 3.0M | $38.0M | 1.1% |
| 30 | enGene Holdings Inc | 5.3M | $35.8M | 1% |
| 31 | PVLAPalvella Therapeutics Inc | 257,485 | $32.1M | 0.9% |
| 32 | Taboola.com Ltd | 10.0M | $30.9M | 0.9% |
| 33 | ELVNEnliven Therapeutics Inc | 746,226 | $29.3M | 0.8% |
| 34 | DNLIDenali Therapeutics Inc | 1.4M | $26.8M | 0.7% |
| 35 | RELYRemitly Global Inc | 1.5M | $24.2M | 0.7% |
| 36 | Damora Therapeutics Inc | 900,000 | $23.3M | 0.6% |
| 37 | Zura Bio Ltd | 3.7M | $22.2M | 0.6% |
| 38 | ANNXAnnexon Inc | 4.0M | $21.9M | 0.6% |
| 39 | TRVITrevi Therapeutics Inc | 1.8M | $21.3M | 0.6% |
| 40 | RAPPRapport Therapeutics Inc | 641,469 | $20.1M | 0.6% |
| 41 | GOOGLAlphabet Inc | 65,703 | $18.9M | 0.5% |
| 42 | FULCFulcrum Therapeutics Inc | 2.4M | $18.0M | 0.5% |
| 43 | WAVE Life Sciences Ltd | 2.5M | $17.8M | 0.5% |
| 44 | DFTXDefinium Therapeutics Inc | 919,493 | $17.4M | 0.5% |
| 45 | AMLXAmylyx Pharmaceuticals Inc | 1.2M | $17.1M | 0.5% |
| 46 | CGEMCullinan Therapeutics Inc | 1.2M | $17.0M | 0.5% |
| 47 | NMRANeumora Therapeutics Inc | 8.5M | $16.6M | 0.5% |
| 48 | Uniqure NV | 1.0M | $16.4M | 0.5% |
| 49 | CTMXCytomX Therapeutics Inc | 3.5M | $16.3M | 0.5% |
| 50 | NVDANVIDIA Corp | 89,085 | $15.5M | 0.4% |
| 51 | SLNSilence Therapeutics PLC | 2.9M | $15.3M | 0.4% |
| 52 | MSFTMicrosoft Corp | 41,380 | $15.3M | 0.4% |
| 53 | MNPRMonopar Therapeutics Inc | 270,118 | $14.8M | 0.4% |
| 54 | TSMTaiwan Semiconductor Manufacturing Co Ltd | 42,200 | $14.3M | 0.4% |
| 55 | SIONSionna Therapeutics Inc | 300,000 | $12.0M | 0.3% |
| 56 | Nebius Group NV | 113,614 | $11.8M | 0.3% |
| 57 | RZLTRezolute Inc | 3.3M | $10.2M | 0.3% |
| 58 | IKTInhibikase Therapeutics Inc | 5.8M | $9.8M | 0.3% |
| 59 | AMZNAmazon.com Inc | 46,641 | $9.7M | 0.3% |
| 60 | GENBGenerate Biomedicines Inc | 736,104 | $9.2M | 0.3% |
| 61 | MPLTMapLight Therapeutics Inc | 450,000 | $9.1M | 0.3% |
| 62 | NOWServiceNow Inc | 87,090 | $9.1M | 0.3% |
| 63 | CRWDCrowdStrike Holdings Inc | 23,070 | $9.0M | 0.2% |
| 64 | PDDPDD Holdings Inc | 83,401 | $8.5M | 0.2% |
| 65 | TSLATesla Inc | 21,500 | $8.0M | 0.2% |
| 66 | NBPNovaBridge Biosciences | 3.0M | $7.4M | 0.2% |
| 67 | BCYCBicycle Therapeutics PLC | 1.6M | $7.2M | 0.2% |
| 68 | WHWKWhitehawk Therapeutics Inc | 2.1M | $7.2M | 0.2% |
| 69 | TENXTenax Therapeutics Inc | 427,141 | $6.8M | 0.2% |
| 70 | VTVTvTv Therapeutics Inc | 163,000 | $6.5M | 0.2% |
| 71 | DDOGDatadog Inc | 54,300 | $6.4M | 0.2% |
| 72 | Jfrog Ltd | 128,816 | $6.0M | 0.2% |
| 73 | DTDynatrace Inc | 150,000 | $5.5M | 0.2% |
| 74 | WKWorkiva Inc | 92,500 | $5.5M | 0.2% |
| 75 | ABSIAbsci Corp | 1.8M | $5.4M | 0.1% |
| 76 | IVVDInvivyd Inc | 4.0M | $5.2M | 0.1% |
| 77 | MSLESatellos Bioscience Inc | 892,074 | $5.0M | 0.1% |
| 78 | IONQIONQ Inc | 170,000 | $4.9M | 0.1% |
| 79 | AVGOBroadcom Inc | 15,000 | $4.6M | 0.1% |
| 80 | AGMBAgomab Therapeutics NV | 411,250 | $4.3M | 0.1% |
| 81 | Cellebrite DI Ltd | 311,544 | $4.3M | 0.1% |
| 82 | SEERSeer Inc | 2.5M | $4.1M | 0.1% |
| 83 | KRROKorro Bio Inc | 347,718 | $3.9M | 0.1% |
| 84 | AGENAgenus Inc | 1.1M | $3.6M | 0.1% |
| 85 | FHTXFoghorn Therapeutics Inc | 720,720 | $3.4M | 0.1% |
| 86 | FPSForgent Power Solutions, Inc | 100,000 | $2.9M | 0.1% |
| 87 | KLRSKalaris Therapeutics Inc | 435,798 | $2.5M | 0.1% |
| 88 | GTLBGitLab Inc | 100,000 | $2.2M | 0.1% |
| 89 | MUMicron Technology Inc | 6,000 | $2.0M | 0.1% |
| 90 | monday.com Ltd | 25,000 | $1.7M | 0% |
| 91 | GOSSGossamer Bio Inc | 5.2M | $1.7M | 0% |
| 92 | Amer Sports Inc | 50,000 | $1.6M | 0% |
| 93 | BEKEKE Holdings Inc | 100,000 | $1.5M | 0% |
| 94 | IREN Ltd | 43,100 | $1.5M | 0% |
| 95 | RANIRani Therapeutics Holdings Inc | 2.0M | $1.5M | 0% |
| 96 | AEVAAeva Technologies Inc | 110,000 | $1.4M | 0% |
| 97 | MDLNMedline Inc | 25,000 | $1.1M | 0% |
| 98 | FIGFigma Inc | 50,000 | $1.1M | 0% |
| 99 | PRMBPrimo Brands Corp | 50,000 | $941,500 | 0% |
| 100 | Nu Holdings Ltd. | 25,000 | $359,250 | 0% |
Source: SEC Form 13F-HR, reporting period 2026-03-31. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.