Who owns Spyre Therapeutics, Inc.?
Institutional ownership of SYRE from SEC Form 13F filings across 169 reporting managers. All positions are from one synchronized reporting period — 2026-06-30 books, filed up to 45 days after quarter end — so every row is comparable.
169
13F holders
$4.99B
value, 2026 filers
68.1%
of shares outstanding (59.2M sh)
53
new positions (2026 filers)
Top institutional holders
ordered by shares owned · positions as of 2026-06-30· % of fund = share of the manager's own book · % of co. = share of SYRE's shares outstanding
| # | Manager | Shares | Value | % of fund | % of co. | Δ shares QoQ |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13.0M | $1.16B | 0.1% | 15% | +10.6% |
| 2 | BlackRock, Inc. | 6.5M | $577.7M | 0.0% | 7.5% | +17.8% |
| 3 | VANGUARD CAPITAL MANAGEMENT LLC | 3.4M | $306.2M | 0.0% | 4% | -43.6% |
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 3.0M | $262,866 | 0.0% | 3.4% | +85.2% |
| 5 | GEODE CAPITAL MANAGEMENT, LLC | 2.6M | $239.3M | 0.0% | 3% | +48.9% |
| 6 | VANGUARD PORTFOLIO MANAGEMENT LLC | 2.3M | $206.9M | 0.0% | 2.7% | +298.2% |
| 7 | Capital World Investors | 2.3M | $205.6M | 0.0% | 2.7% | +247.4% |
| 8 | Jupiter Topco LLCNEW | 2.2M | $195.9M | 0.1% | 2.5% | new |
| 9 | BANK OF AMERICA CORP /DE/ | 1.8M | $157.8M | 0.0% | 2% | +44.8% |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C.NEW | 1.7M | $152.9M | 0.2% | 2% | new |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 1.6M | $140.4M | 0.0% | 1.8% | -13.3% |
| 12 | GOLDMAN SACHS GROUP INC | 1.5M | $131.2M | 0.0% | 1.7% | +447.6% |
| 13 | FRANKLIN RESOURCES INC | 1.5M | $130.8M | 0.0% | 1.7% | +66.8% |
| 14 | JPMORGAN CHASE & CO | 1.1M | $98.9M | 0.0% | 1.3% | +11.6% |
| 15 | MARSHALL WACE, LLP | 991,693 | $88.0M | 0.1% | 1.1% | +612.1% |
| 16 | Capital International Investors | 955,196 | $84.8M | 0.0% | 1.1% | -45.3% |
| 17 | UBS Group AG | 843,071 | $74.8M | 0.0% | 1% | +25.6% |
| 18 | NORTHERN TRUST CORP | 674,529 | $59.9M | 0.0% | 0.8% | +16.5% |
| 19 | Sixth Street Partners Management Company, L.P.NEW | 652,958 | $58.0M | 10.0% | 0.8% | new |
| 20 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 652,958 | $58.0M | 0.0% | 0.8% | +16.0% |
| 21 | Pictet Asset Management Holding SA | 628,138 | $55.8M | 0.1% | 0.7% | +27.8% |
| 22 | VICTORY CAPITAL MANAGEMENT INC | 553,980 | $49.2M | 0.0% | 0.6% | +89.6% |
| 23 | VANGUARD FIDUCIARY TRUST CO | 551,389 | $49.0M | 0.0% | 0.6% | +18.7% |
| 24 | Candriam S.C.A. | 546,312 | $48.5M | 0.2% | 0.6% | -10.5% |
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 522,071 | $46.3M | 0.0% | 0.6% | +151.8% |
Source: SEC Form 13F-HR filings (institutional managers over $100M in US-listed positions). 13Fs disclose long positions only, up to 45 days after quarter end; each manager's latest filed quarter is shown per row and dollar values are the manager's filed marks. Aggregates labeled "2026 filers" count only managers whose latest book is a 2026 quarter. Related: valuation · options positioning · supply chain. Research, not investment advice.