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Paradigm Biocapital Advisors LP

Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-06-30 · filed with the SEC up to 45 days after quarter end · CIK 0001855655

$5.34B

disclosed book value

28

positions

22.3%

largest position share

Positions, as of 2026-06-30

top 28 of 28 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held

#IssuerSharesValue% of book
1RVMDREVOLUTION MEDICINES INC6.4M$1.19B22.3%
2NUVALENT INC5.9M$731.7M13.7%
3EWTXEDGEWISE THERAPEUTICS INC10.2M$415.1M7.8%
4GMABGENMAB A/S13.1M$360.8M6.8%
5SYRESPYRE THERAPEUTICS INC3.8M$341.0M6.4%
6APGEAPOGEE THERAPEUTICS INC1.6M$209.2M3.9%
7ORKAORUKA THERAPEUTICS INC2.1M$204.1M3.8%
8TNGXTANGO THERAPEUTICS INC6.4M$198.7M3.7%
9BLTEBELITE BIO INC1.2M$189.8M3.6%
10ERASERASCA INC9.6M$175.0M3.3%
11TARSTARSUS PHARMACEUTICALS INC2.8M$174.7M3.3%
12ALNYALNYLAM PHARMACEUTICALS INC480,000$144.5M2.7%
13INSMINSMED INC1.3M$141.4M2.6%
14MBXMBX BIOSCIENCES INC2.5M$138.4M2.6%
15PCVXVAXCYTE INC2.1M$123.7M2.3%
16VRDNVIRIDIAN THERAPEUTICS INC6.7M$123.5M2.3%
17OLMAOLEMA PHARMACEUTICALS INC8.7M$108.5M2%
18JBIOJADE BIOSCIENCES INC2.9M$63.5M1.2%
19TYRATYRA BIOSCIENCES INC1.8M$58.4M1.1%
20ASMBASSEMBLY BIOSCIENCES INC1.6M$42.7M0.8%
21EYPTEYEPOINT INC2.9M$41.3M0.8%
22ACHVACHIEVE LIFE SCIENCE INC5.0M$32.3M0.6%
23VORVOR BIOPHARMA INC1.8M$32.2M0.6%
24MPLTMAPLIGHT THERAPEUTICS INC685,852$24.6M0.5%
25KARDKARDIGAN INC900,000$21.5M0.4%
26LXEOLEXEO THERAPEUTICS INC4.2M$19.4M0.4%
27EDITEDITAS MEDICINE INC5.6M$18.1M0.3%
28IVAINVENTIVA SA4.0M$15.1M0.3%

Source: SEC Form 13F-HR, reporting period 2026-06-30. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.

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