Holders — by stockHoldings — by fund
ORBIMED ADVISORS LLC
Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-06-30 · filed with the SEC up to 45 days after quarter end · CIK 1055951
$5.40B
disclosed book value
123
positions
11.7%
largest position share
Positions, as of 2026-06-30
top 100 of 123 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held
| # | Issuer | Shares | Value | % of book |
|---|---|---|---|---|
| 1 | EWTXEDGEWISE THERAPEUTICS INC | 15.5M | $630.5M | 11.7% |
| 2 | ELVNENLIVEN THERAPEUTICS INC | 6.8M | $343.9M | 6.4% |
| 3 | LLYELI LILLY & CO | 257,900 | $309.3M | 5.7% |
| 4 | MBXMBX BIOSCIENCES INC | 3.4M | $189.3M | 3.5% |
| 5 | SINOVAC BIOTECH LTD | 2.7M | $184.5M | 3.4% |
| 6 | ASTRAZENECA PLC | 915,700 | $171.1M | 3.2% |
| 7 | GPCRSTRUCTURE THERAPEUTICS INC | 2.2M | $118.6M | 2.2% |
| 8 | SIONSIONNA THERAPEUTICS INC | 2.6M | $112.4M | 2.1% |
| 9 | CRVSCORVUS PHARMACEUTICALS INC | 7.2M | $107.0M | 2% |
| 10 | AVBPARRIVENT BIOPHARMA INC | 3.0M | $105.2M | 1.9% |
| 11 | GHGUARDANT HEALTH INC | 583,700 | $87.6M | 1.6% |
| 12 | ARGXARGENX SE | 92,880 | $86.2M | 1.6% |
| 13 | MRKMERCK & CO INC | 663,400 | $85.2M | 1.6% |
| 14 | UNIQURE NV | 1.8M | $83.3M | 1.5% |
| 15 | PRAXPRAXIS PRECISION MEDICINES I | 230,100 | $77.0M | 1.4% |
| 16 | EWEDWARDS LIFESCIENCES CORP | 834,900 | $75.5M | 1.4% |
| 17 | PRLDPRELUDE THERAPEUTICS INC | 13.7M | $73.2M | 1.4% |
| 18 | ABVXABIVAX SA | 546,522 | $72.8M | 1.3% |
| 19 | DYNDYNE THERAPEUTICS INC | 3.2M | $71.9M | 1.3% |
| 20 | NTRANATERA INC | 262,000 | $71.1M | 1.3% |
| 21 | CGONCG ONCOLOGY INC | 972,800 | $69.1M | 1.3% |
| 22 | UNHUNITEDHEALTH GROUP INC | 161,100 | $67.0M | 1.2% |
| 23 | SPRYARS PHARMACEUTICALS INC | 8.3M | $66.4M | 1.2% |
| 24 | ASCENDIS PHARMA A/S | 244,456 | $65.2M | 1.2% |
| 25 | HUMHUMANA INC | 164,100 | $65.2M | 1.2% |
| 26 | COGTCOGENT BIOSCIENCES INC | 1.7M | $65.1M | 1.2% |
| 27 | BSXBOSTON SCIENTIFIC CORP | 1.5M | $63.3M | 1.2% |
| 28 | ISRGINTUITIVE SURGICAL INC | 157,900 | $62.8M | 1.2% |
| 29 | MLYSMINERALYS THERAPEUTICS INC | 2.1M | $56.9M | 1.1% |
| 30 | ODTXODYSSEY THERAPEUTICS INC | 3.0M | $56.2M | 1% |
| 31 | XENEXENON PHARMACEUTICALS INC | 892,471 | $53.9M | 1% |
| 32 | ARQTARCUTIS BIOTHERAPEUTICS INC | 2.0M | $53.5M | 1% |
| 33 | BMYBRISTOL-MYERS SQUIBB CO | 925,000 | $53.3M | 1% |
| 34 | QTTBQ32 BIO INC | 4.1M | $52.6M | 1% |
| 35 | SYKSTRYKER CORPORATION | 159,100 | $50.1M | 0.9% |
| 36 | CAICARIS LIFE SCIENCES INC | 2.8M | $50.0M | 0.9% |
| 37 | XBISPDR SERIES TRUSTPUT | 300,000 | $47.5M | 0.9% |
| 38 | TMOTHERMO FISHER SCIENTIFIC INC | 90,700 | $45.5M | 0.8% |
| 39 | PVLAPALVELLA THERAPEUTICS INC NE | 292,360 | $44.7M | 0.8% |
| 40 | ELVELEVANCE HEALTH INC FORMERLY | 114,700 | $44.4M | 0.8% |
| 41 | STTKSHATTUCK LABS INC | 6.3M | $43.8M | 0.8% |
| 42 | UPBUPSTREAM BIO INC | 5.7M | $39.4M | 0.7% |
| 43 | CRNXCRINETICS PHARMACEUTICALS IN | 999,000 | $37.4M | 0.7% |
| 44 | RYTMRHYTHM PHARMACEUTICALS INC | 322,900 | $35.9M | 0.7% |
| 45 | SNDXSYNDAX PHARMACEUTICALS INC | 1.5M | $33.7M | 0.6% |
| 46 | FBRXFORTE BIOSCIENCES INC | 1.6M | $33.5M | 0.6% |
| 47 | CMPXCOMPASS THERAPEUTICS INC | 15.2M | $33.3M | 0.6% |
| 48 | NKTRNEKTAR THERAPEUTICS | 465,346 | $32.5M | 0.6% |
| 49 | KRYSKRYSTAL BIOTECH INC | 83,200 | $30.9M | 0.6% |
| 50 | PRELUDE THERAPEUTICS INC | 5.7M | $30.3M | 0.6% |
| 51 | AXSMAXSOME THERAPEUTICS INC. | 117,578 | $28.8M | 0.5% |
| 52 | KINIKSA PHARMACEUTICALS INTL | 420,600 | $26.9M | 0.5% |
| 53 | TRVITREVI THERAPEUTICS INC | 1.4M | $26.7M | 0.5% |
| 54 | ABVXABIVAX SACALL | 200,000 | $26.7M | 0.5% |
| 55 | IRONDISC MEDICINE INC | 357,535 | $26.2M | 0.5% |
| 56 | WSTWEST PHARMACEUTICAL SVSC INC | 70,600 | $25.3M | 0.5% |
| 57 | RLMDRELMADA THERAPEUTICS INC | 3.6M | $25.1M | 0.5% |
| 58 | UROGEN PHARMA LTD | 676,187 | $24.9M | 0.5% |
| 59 | STROSUTRO BIOPHARMA INC | 743,944 | $24.7M | 0.5% |
| 60 | SVRASAVARA INC | 4.0M | $24.4M | 0.5% |
| 61 | NPCENEUROPACE INC | 1.5M | $23.9M | 0.4% |
| 62 | AURAAURA BIOSCIENCES INC | 3.3M | $23.7M | 0.4% |
| 63 | ORICORIC PHARMACEUTICALS INC | 2.0M | $21.8M | 0.4% |
| 64 | HELPCYBIN INC | 3.3M | $21.6M | 0.4% |
| 65 | BCRXBIOCRYST PHARMACEUTICALS INC | 1.9M | $18.5M | 0.3% |
| 66 | BIOABIOAGE LABS INC | 752,153 | $18.4M | 0.3% |
| 67 | PTGXPROTAGONIST THERAPEUTICS INCCALL | 150,000 | $18.4M | 0.3% |
| 68 | LXEOLEXEO THERAPEUTICS INC | 3.9M | $18.4M | 0.3% |
| 69 | WHWKWHITEHAWK THERAPEUTICS INC | 3.9M | $18.0M | 0.3% |
| 70 | DFTXDEFINIUM THERAPEUTICS INC | 365,400 | $17.2M | 0.3% |
| 71 | SYRESPYRE THERAPEUTICS INC | 186,145 | $16.5M | 0.3% |
| 72 | CRBPCORBUS PHARMACEUTICALS HLDGS | 1.7M | $16.3M | 0.3% |
| 73 | VERAVERA THERAPEUTICS INC | 369,596 | $15.9M | 0.3% |
| 74 | ALMSALUMIS INC | 548,163 | $15.4M | 0.3% |
| 75 | EYPTEYEPOINT INC | 1.1M | $15.3M | 0.3% |
| 76 | WATWATERS CORP | 40,300 | $15.1M | 0.3% |
| 77 | MNPRMONOPAR THERAPEUTICS INC | 157,423 | $14.6M | 0.3% |
| 78 | TVTXTRAVERE THERAPEUTICS INC | 253,000 | $14.4M | 0.3% |
| 79 | TSHATAYSHA GENE THERAPIES INC | 2.0M | $13.6M | 0.3% |
| 80 | BIIBBIOGEN INC | 61,600 | $13.3M | 0.2% |
| 81 | RVMDREVOLUTION MEDICINES INC | 70,500 | $13.2M | 0.2% |
| 82 | DNTHDIANTHUS THERAPEUTICS INC | 115,000 | $11.2M | 0.2% |
| 83 | SPRBSPRUCE BIOSCIENCES INC | 200,000 | $10.8M | 0.2% |
| 84 | LFSTLIFESTANCE HEALTH GROUP INC | 947,400 | $10.1M | 0.2% |
| 85 | RVMDREVOLUTION MEDICINES INCCALL | 50,000 | $9.4M | 0.2% |
| 86 | ERASERASCA INC | 495,900 | $9.1M | 0.2% |
| 87 | TARAPROTARA THERAPEUTICS INC | 2.2M | $8.5M | 0.2% |
| 88 | KROSKEROS THERAPEUTICS INC | 759,155 | $8.1M | 0.2% |
| 89 | JANXJANUX THERAPEUTICS INC | 524,700 | $8.1M | 0.1% |
| 90 | TECXTECTONIC THERAPEUTIC INC | 226,600 | $7.8M | 0.1% |
| 91 | ACETADICET BIO INC | 844,787 | $7.3M | 0.1% |
| 92 | PHARVARIS N V | 205,400 | $7.1M | 0.1% |
| 93 | ANROALTO NEUROSCIENCE INC | 257,852 | $6.8M | 0.1% |
| 94 | ZNTLZENTALIS PHARMACEUTICALS INC | 1.4M | $6.7M | 0.1% |
| 95 | DRUGBRIGHT MINDS BIOSCIENCES INC | 93,000 | $6.5M | 0.1% |
| 96 | PVLAPALVELLA THERAPEUTICS INC NECALL | 40,000 | $6.1M | 0.1% |
| 97 | ALXOALX ONCOLOGY HLDGS INC | 2.9M | $5.9M | 0.1% |
| 98 | TVTX 0.5 05/15/32TRAVERE THERAPEUTICS INC | 5.0M | $5.9M | 0.1% |
| 99 | XLOXILIO THERAPEUTICS INC | 592,300 | $5.7M | 0.1% |
| 100 | BCAXBICARA THERAPEUTICS INC | 191,100 | $5.7M | 0.1% |
Source: SEC Form 13F-HR, reporting period 2026-06-30. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.