Holders — by stockHoldings — by fund
SPHERA FUNDS MANAGEMENT LTD.
Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-06-30 · filed with the SEC up to 45 days after quarter end · CIK 0001496201
$766.5M
disclosed book value
101
positions
6.6%
largest position share
Positions, as of 2026-06-30
top 100 of 101 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held
| # | Issuer | Shares | Value | % of book |
|---|---|---|---|---|
| 1 | TEVATEVA PHARMACEUTICAL INDS LTD | 1.5M | $50.8M | 6.6% |
| 2 | MLYSMINERALYS THERAPEUTICS INC | 1.5M | $39.7M | 5.2% |
| 3 | TOWER SEMICONDUCTOR LTD | 108,265 | $28.2M | 3.7% |
| 4 | XBISPDR SERIES TRUSTPUT | 150,000 | $23.7M | 3.1% |
| 5 | SNDXSYNDAX PHARMACEUTICALS INC | 1.0M | $22.2M | 2.9% |
| 6 | BIIBBIOGEN INCCALL | 100,000 | $21.6M | 2.8% |
| 7 | BIIBBIOGEN INC | 96,626 | $20.9M | 2.7% |
| 8 | RAREULTRAGENYX PHARMACEUTICAL IN | 588,494 | $19.6M | 2.6% |
| 9 | BMRNBIOMARIN PHARMACEUTICAL INC | 328,550 | $18.8M | 2.5% |
| 10 | CYTKCYTOKINETICS INC | 219,987 | $18.7M | 2.4% |
| 11 | BBIOBRIDGEBIO PHARMA INC | 245,346 | $18.3M | 2.4% |
| 12 | COGTCOGENT BIOSCIENCES INC | 459,340 | $17.8M | 2.3% |
| 13 | NOVA LTD | 25,169 | $13.7M | 1.8% |
| 14 | INSMINSMED INC | 118,800 | $12.7M | 1.7% |
| 15 | MAZEMAZE THERAPEUTICS INC | 417,564 | $12.5M | 1.6% |
| 16 | ASTRAZENECA PLC | 62,530 | $11.9M | 1.5% |
| 17 | SNYSANOFI SA | 269,515 | $11.5M | 1.5% |
| 18 | HELPCYBIN INC | 1.6M | $10.7M | 1.4% |
| 19 | LLYELI LILLY & CO | 8,040 | $9.6M | 1.3% |
| 20 | MDGLMADRIGAL PHARMACEUTICALS INC | 17,419 | $9.4M | 1.2% |
| 21 | TRVITREVI THERAPEUTICS INC | 499,029 | $9.3M | 1.2% |
| 22 | ACADACADIA PHARMACEUTICALS INC | 356,534 | $9.0M | 1.2% |
| 23 | CLDXCELLDEX THERAPEUTICS INC NEW | 240,868 | $9.0M | 1.2% |
| 24 | RYTMRHYTHM PHARMACEUTICALS INC | 80,400 | $8.9M | 1.2% |
| 25 | CYTKCYTOKINETICS INCCALL | 100,000 | $8.5M | 1.1% |
| 26 | ORICORIC PHARMACEUTICALS INC | 752,983 | $8.2M | 1.1% |
| 27 | LRCXLAM RESEARCH CORP | 18,470 | $8.0M | 1% |
| 28 | AMATAPPLIED MATLS INC | 11,040 | $8.0M | 1% |
| 29 | TNGXTANGO THERAPEUTICS INC | 254,250 | $7.9M | 1% |
| 30 | NVSNOVARTIS AG | 50,000 | $7.8M | 1% |
| 31 | SEDG 2.25 07/01/29SOLAREDGE TECHNOLOGIES INC | 4.0M | $7.7M | 1% |
| 32 | VORVOR BIOPHARMA INC | 416,417 | $7.7M | 1% |
| 33 | ABBVABBVIE INC | 30,256 | $7.6M | 1% |
| 34 | MRKMERCK & CO INC | 58,600 | $7.5M | 1% |
| 35 | JNJJOHNSON & JOHNSON | 28,831 | $7.3M | 1% |
| 36 | IDYAIDEAYA BIOSCIENCES INC | 196,408 | $7.3M | 1% |
| 37 | IMMATICS N.V | 720,057 | $7.3M | 1% |
| 38 | NVCTNUVECTIS PHARMA INC | 382,945 | $7.0M | 0.9% |
| 39 | PFEPFIZER INC | 286,000 | $6.9M | 0.9% |
| 40 | HRMYHARMONY BIOSCIENCES HLDGS IN | 176,663 | $6.4M | 0.8% |
| 41 | XENEXENON PHARMACEUTICALS INC | 105,000 | $6.3M | 0.8% |
| 42 | CLYMCLIMB BIO INC | 483,747 | $6.3M | 0.8% |
| 43 | ZBIOZENAS BIOPHARMA INC | 230,834 | $5.9M | 0.8% |
| 44 | NVONOVO-NORDISK A S | 120,677 | $5.8M | 0.8% |
| 45 | ELVNENLIVEN THERAPEUTICS INC | 112,765 | $5.7M | 0.7% |
| 46 | PRLDPRELUDE THERAPEUTICS INC | 1.0M | $5.4M | 0.7% |
| 47 | GSKGSK PLC | 102,000 | $5.3M | 0.7% |
| 48 | FBRXFORTE BIOSCIENCES INC | 249,693 | $5.3M | 0.7% |
| 49 | BIOABIOAGE LABS INC | 213,671 | $5.2M | 0.7% |
| 50 | SRRKSCHOLAR ROCK HLDG CORP | 94,265 | $5.2M | 0.7% |
| 51 | MSLESATELLOS BIOSCIENCE INC | 652,590 | $5.1M | 0.7% |
| 52 | PALIPALISADE BIO INC | 2.3M | $4.7M | 0.6% |
| 53 | ELDNELEDON PHARMACEUTICALS INC | 1.2M | $4.7M | 0.6% |
| 54 | VSTVISTRA CORP | 29,450 | $4.7M | 0.6% |
| 55 | TLNTALEN ENERGY CORP | 12,135 | $4.7M | 0.6% |
| 56 | SVRASAVARA INC | 756,164 | $4.7M | 0.6% |
| 57 | IRONDISC MEDICINE INC | 63,538 | $4.6M | 0.6% |
| 58 | CLOUGLOBAL X FDS | 195,900 | $4.5M | 0.6% |
| 59 | DYNDYNE THERAPEUTICS INC | 199,594 | $4.4M | 0.6% |
| 60 | RLAYRELAY THERAPEUTICS INC | 233,836 | $4.4M | 0.6% |
| 61 | AVTXAVALO THERAPEUTICS INC | 232,294 | $4.3M | 0.6% |
| 62 | PMNPROMIS NEUROSCIENCES INC | 325,591 | $4.3M | 0.6% |
| 63 | BCRXBIOCRYST PHARMACEUTICALS INC | 422,051 | $4.2M | 0.6% |
| 64 | RVMDREVOLUTION MEDICINES INC | 22,400 | $4.2M | 0.5% |
| 65 | PRAXPRAXIS PRECISION MEDICINES ICALL | 12,500 | $4.2M | 0.5% |
| 66 | CABACABALETTA BIO INC | 1.3M | $4.1M | 0.5% |
| 67 | GENBGENERATE BIOMEDICINES INC | 245,000 | $4.1M | 0.5% |
| 68 | TLTISHARES TRCALL | 47,000 | $4.1M | 0.5% |
| 69 | MEDIWOUND LTD | 273,192 | $4.0M | 0.5% |
| 70 | ACOGALPHA COGNITION INC | 545,816 | $3.9M | 0.5% |
| 71 | WAVE LIFE SCIENCES LTD | 638,272 | $3.7M | 0.5% |
| 72 | CRVSCORVUS PHARMACEUTICALS INC | 244,961 | $3.7M | 0.5% |
| 73 | OVIDOVID THERAPEUTICS INC | 1.4M | $3.6M | 0.5% |
| 74 | BBOTBRIDGEBIO ONCOLOGY THERAPEUT | 460,985 | $3.5M | 0.5% |
| 75 | CTMXCYTOMX THERAPEUTICS INC. | 879,000 | $3.3M | 0.4% |
| 76 | PROQR THRAPEUTICS N V | 1.8M | $3.3M | 0.4% |
| 77 | ALNYALNYLAM PHARMACEUTICALS INC | 10,800 | $3.3M | 0.4% |
| 78 | KURAKURA ONCOLOGY INC | 295,039 | $3.2M | 0.4% |
| 79 | KODKODIAK SCIENCES INC | 81,796 | $3.2M | 0.4% |
| 80 | ORAORMAT TECHNOLOGIES INC | 28,015 | $3.1M | 0.4% |
| 81 | CTNMCONTINEUM THERAPEUTICS INC | 183,475 | $3.0M | 0.4% |
| 82 | LRMRLARIMAR THERAPEUTICS INC | 926,004 | $2.8M | 0.4% |
| 83 | IMMXIMMIX BIOPHARMA INC | 270,000 | $2.8M | 0.4% |
| 84 | AMGNAMGEN INC | 7,500 | $2.7M | 0.4% |
| 85 | ABVXABIVAX SAPUT | 20,000 | $2.7M | 0.3% |
| 86 | BIOHAVEN LTD | 164,437 | $2.4M | 0.3% |
| 87 | CEGCONSTELLATION ENERGY CORP | 9,850 | $2.4M | 0.3% |
| 88 | VSTMVERASTEM INC | 632,632 | $2.4M | 0.3% |
| 89 | TENXTENAX THERAPEUTICS INCCALL | 127,600 | $1.9M | 0.2% |
| 90 | TENXTENAX THERAPEUTICS INC | 120,200 | $1.7M | 0.2% |
| 91 | TSHATAYSHA GENE THERAPIES INC | 250,000 | $1.7M | 0.2% |
| 92 | GPCRSTRUCTURE THERAPEUTICS INC | 28,600 | $1.5M | 0.2% |
| 93 | UPBUPSTREAM BIO INC | 219,700 | $1.5M | 0.2% |
| 94 | VYGRVOYAGER THERAPEUTICS INC | 427,554 | $1.5M | 0.2% |
| 95 | ORGOORGANOGENESIS HLDGS INC | 550,000 | $1.3M | 0.2% |
| 96 | IKTINHIBIKASE THERAPEUTICS INC | 649,309 | $1.3M | 0.2% |
| 97 | ORICORIC PHARMACEUTICALS INCCALL | 100,000 | $1.1M | 0.1% |
| 98 | CRISEURCURIS INC | 98,996 | $1.0M | 0.1% |
| 99 | STTKSHATTUCK LABS INC | 86,461 | $600,039 | 0.1% |
| 100 | TRAXFIRST TRACKS BIOTHERAPEUTICS | 27,876 | $560,865 | 0.1% |
Source: SEC Form 13F-HR, reporting period 2026-06-30. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.