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Holders — by stockHoldings — by fund

Sofinnova Investments, Inc.

Everything this manager disclosed owning in US-listed stocks — its complete Form 13F portfolio · as of 2026-06-30 · filed with the SEC up to 45 days after quarter end · CIK 0001631134

$1.93B

disclosed book value

56

positions

21.8%

largest position share

Positions, as of 2026-06-30

top 57 of 56 · 13F covers long US-listed positions only — cash, bonds, private and foreign stakes are not disclosed · PUT/CALL tags = options positions (share-equivalents), not shares held

#IssuerSharesValue% of book
1NTRANatera Inc1.6M$420.8M21.8%
2VERAVera Therapeutics Inc2.8M$119.9M6.2%
3GMABGenmab A/S4.0M$111.1M5.7%
4JAZZJazz Pharmaceuticals PLC365,341$88.0M4.6%
5RAPPRapport Therapeutics Inc1.9M$79.4M4.1%
6SPTXSeaport Therapeutics Inc3.6M$77.4M4%
7AVBPArrivent BioPharma Inc1.7M$58.9M3%
8RAREUltragenyx Pharmaceutical In1.7M$57.3M3%
9BIOABioAge Labs Inc2.3M$56.2M2.9%
10BMYBristol-Myers Squibb Co876,970$50.5M2.6%
11SUPNSupernus Pharmaceuticals1.0M$48.2M2.5%
12RYTMRhythm Pharmaceuticals Inc408,027$45.3M2.3%
13GILDGilead Sciences Inc343,100$43.3M2.2%
14UTHRUnited Therapeutics Corp Del76,489$41.4M2.1%
15COGTCogent Biosciences Inc1.0M$40.1M2.1%
16AXSMAxsome Therapeutics Inc.160,429$39.3M2%
17IMTXImmatics N.V3.7M$37.2M1.9%
18DYNDyne Therapeutics Inc1.7M$36.8M1.9%
19IMNMImmunome Inc1.7M$36.5M1.9%
20IDYAIDEAYA Biosciences Inc925,119$34.5M1.8%
21ANABAnaptysbio Inc493,536$33.3M1.7%
22NKTRNektar Therapeutics471,763$32.9M1.7%
23PHVSPharvaris N V881,299$30.5M1.6%
24RCUSArcus Biosciences Inc945,690$29.2M1.5%
25INBXInhibrx Biosciences Inc303,103$28.7M1.5%
26BMRNBioMarin Pharmaceutical Inc358,568$20.5M1.1%
27MANEVeradermics Inc148,993$18.3M0.9%
28ALCAlcon AG255,824$17.2M0.9%
29INSMInsmed Inc158,398$16.9M0.9%
30RAREUltragenyx Pharmaceutical InCALL500,000$16.7M0.9%
31ISRGIntuitive Surgical IncCALL40,000$15.9M0.8%
32GMEDGlobus Med IncCALL200,000$15.8M0.8%
33EWTXEdgewise Therapeutics Inc380,923$15.5M0.8%
34EXELExelixis IncPUT254,200$13.8M0.7%
35NRIXNurix Therapeutics Inc524,098$12.7M0.7%
36DSGNDesign Therapeutics Inc865,135$12.5M0.6%
37DFTXDefinium Therapeutics Inc255,903$12.0M0.6%
38TRAXFirst Tracks Biotherapeutics565,199$11.4M0.6%
39ABTAbbott Laboratories122,998$11.2M0.6%
40IRONDisc Medicine Inc146,239$10.7M0.6%
41TENXTenax Therapeutics Inc500,039$7.3M0.4%
42SIONSionna Therapeutics Inc144,432$6.4M0.3%
43ABSIAbsci Corporation337,400$3.9M0.2%
44MIRMMirum Pharmaceuticals Inc27,591$3.2M0.2%
45JBIOJade Biosciences Inc107,391$2.4M0.1%
46SVRASavara Inc364,763$2.2M0.1%
47PRAXPraxis Precision Medicines I6,440$2.2M0.1%
48SEPNSepterna Inc47,506$1.6M0.1%
49OKUROnkure Therapeutics Inc321,692$1.5M0.1%
50SGMTSagimet Biosciences Inc166,667$1.3M0.1%
51WVEWave Life Sciences Ltd189,253$1.1M0.1%
52AKTSAktis Oncology Inc32,436$1.0M0.1%
53TYRATyra Biosciences Inc32,267$1.0M0.1%
54BOLTBolt Biotherapeutics Inc137,721$530,2260%
55NXTCNextcure Inc222,654$356,2460%
56IMAImageneBio Inc31,884$188,1160%
57HTFLHeartflow Inc5,079$149,0180%

Source: SEC Form 13F-HR, reporting period 2026-06-30. Values are the manager's filed June-30-style quarter-end marks, not live prices. Research, not investment advice.

EvidInvest is an independent research and information tool. Figures are calculated from public SEC filings and third-party market data and are provided for informational and educational purposes only. EvidInvest does not provide investment advice, brokerage, or financial services, and is not affiliated with any company it covers. Verify all figures against primary sources before making any decision.